About Killer cell lectin-like receptor subfamily B member 1
Killer cell lectin-like receptor subfamily B member 1 (KLRB1) is a protein
from Homo sapiens identified by UniProt accession
Q12918, 225 residues long.
MolForge cross-references it against 0 known binders and
348 disease associations.
Target properties
| Protein name | Killer cell lectin-like receptor subfamily B member 1 |
|---|
| UniProt accession | Q12918 |
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| Gene | KLRB1 |
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| Organism | Homo sapiens |
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| Length | 225 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (348)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.35
- neoplasm · score 0.11
- cancer · score 0.11
- Rheumatoid arthritis · score 0.11
- breast cancer · score 0.11
- psoriasis · score 0.09
- lung adenocarcinoma · score 0.09
- hepatocellular carcinoma · score 0.09
- juvenile idiopathic arthritis · score 0.08
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12918-F1 | alphafold | PREDICTED | 80.98 | — |
Amino-acid sequence (225 residues)
MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL LVLVVTGLSV SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ LREKCLLFSH TVNPWNNSLA DCSTKESSLL LIRDKDELIH TQNLIRDKAI LFWIGLNFSL SEKNWKWING SFLNSNDLEI RGDAKENSCI SISQTSVYSE YCSTEIRWIC QKELTPVRNK VYPDS
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