ELAV-like protein 2 (ELAVL2)

About ELAV-like protein 2

ELAV-like protein 2 (ELAVL2) is a protein from Homo sapiens identified by UniProt accession Q12926, 359 residues long. MolForge cross-references it against 0 known binders and 295 disease associations.

Target properties

Protein name	ELAV-like protein 2
UniProt accession	Q12926
Gene	ELAVL2
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (295)

Diseases linked to this target (Open Targets).

neuroticism measurement · score 0.50
neurodegenerative disease · score 0.49
mathematical ability · score 0.47
self reported educational attainment · score 0.46
cognitive function measurement · score 0.44
wellbeing measurement · score 0.44
depressive symptom measurement · score 0.44
unipolar depression · score 0.42
intelligence · score 0.41
asthma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12926-F1	alphafold	PREDICTED	75.44	—

Amino-acid sequence (359 residues)

METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards