About Heat shock protein 75 kDa, mitochondrial
Heat shock protein 75 kDa, mitochondrial (TRAP1) is a protein
from Homo sapiens identified by UniProt accession
Q12931, 704 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Heat shock protein 75 kDa, mitochondrial |
|---|
| UniProt accession | Q12931 |
|---|
| Gene | TRAP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 704 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (88)
Diseases linked to this target (Open Targets).
- congenital anomaly of kidney and urinary tract · score 0.65
- VACTERL/vater association · score 0.46
- neutrophil count · score 0.42
- myeloid white cell count · score 0.38
- leukocyte count · score 0.38
- neurodegenerative disease · score 0.37
- glomerular filtration rate · score 0.36
- urate measurement · score 0.35
- congenital hydronephrosis · score 0.33
- congenital anomalies of kidney and urinary tract 1 · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12931-F1 | alphafold | PREDICTED | 86.02 | — |
Amino-acid sequence (704 residues)
MARELRALLL WGRRLRPLLR APALAAVPGG KPILCPRRTT AQLGPRRNPA WSLQAGRLFS TQTAEDKEEP LHSIISSTES VQGSTSKHEF QAETKKLLDI VARSLYSEKE VFIRELISNA SDALEKLRHK LVSDGQALPE MEIHLQTNAE KGTITIQDTG IGMTQEELVS NLGTIARSGS KAFLDALQNQ AEASSKIIGQ FGVGFYSAFM VADRVEVYSR SAAPGSLGYQ WLSDGSGVFE IAEASGVRTG TKIIIHLKSD CKEFSSEARV RDVVTKYSNF VSFPLYLNGR RMNTLQAIWM MDPKDVREWQ HEEFYRYVAQ AHDKPRYTLH YKTDAPLNIR SIFYVPDMKP SMFDVSRELG SSVALYSRKV LIQTKATDIL PKWLRFIRGV VDSEDIPLNL SRELLQESAL IRKLRDVLQQ RLIKFFIDQS KKDAEKYAKF FEDYGLFMRE GIVTATEQEV KEDIAKLLRY ESSALPSGQL TSLSEYASRM RAGTRNIYYL CAPNRHLAEH SPYYEAMKKK DTEVLFCFEQ FDELTLLHLR EFDKKKLISV ETDIVVDHYK EEKFEDRSPA AECLSEKETE ELMAWMRNVL GSRVTNVKVT LRLDTHPAMV TVLEMGAARH FLRMQQLAKT QEERAQLLQP TLEINPRHAL IKKLNQLRAS EPGLAQLLVD QIYENAMIAA GLVDDPRAMV GRLNELLVKA LERH
Explore Heat shock protein 75 kDa, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets