TNF receptor-associated factor 2 (TRAF2)

About TNF receptor-associated factor 2

TNF receptor-associated factor 2 (TRAF2) is a protein from Homo sapiens identified by UniProt accession Q12933, 501 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	TNF receptor-associated factor 2
UniProt accession	Q12933
Gene	TRAF2
Organism	Homo sapiens
Length	501 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

genetic disorder · score 0.37
ovarian cancer · score 0.26
breast adenocarcinoma · score 0.26
lung adenocarcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.18
neurodegenerative disease · score 0.18
esophageal cancer · score 0.16
breast carcinoma · score 0.15
platelet component distribution width · score 0.12
lymphocyte:monocyte ratio · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12933-F1	alphafold	PREDICTED	90.21	—

Amino-acid sequence (501 residues)

MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE YESCHEGRCP LMLTECPACK GLVRLGEKER HLEHECPERS LSCRHCRAPC CGADVKAHHE VCPKFPLTCD GCGKKKIPRE KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL REHLAMLLSS VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA EACSRQHRLD QDKIEALSSK VQQLERSIGL KDLAMADLEQ KVLEMEASTY DGVFIWKISD FARKRQEAVA GRIPAIFSPA FYTSRYGYKM CLRIYLNGDG TGRGTHLSLF FVVMKGPNDA LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD VTSSSFQRPV NDMNIASGCP LFCPVSKMEA KNSYVRDDAI FIKAIVDLTG L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards