Forkhead box protein F1 (FOXF1)

About Forkhead box protein F1

Forkhead box protein F1 (FOXF1) is a protein from Homo sapiens identified by UniProt accession Q12946, 379 residues long. MolForge cross-references it against 0 known binders and 271 disease associations.

Target properties

Protein name	Forkhead box protein F1
UniProt accession	Q12946
Gene	FOXF1
Organism	Homo sapiens
Length	379 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (271)

Diseases linked to this target (Open Targets).

alveolar capillary dysplasia with misalignment of pulmonary veins · score 0.80
Congenital alveolar capillary dysplasia · score 0.77
lean body mass · score 0.42
appendicular lean mass · score 0.42
anorectal malformation · score 0.37
cup-to-disc ratio measurement · score 0.36
FEV/FVC ratio · score 0.35
body height · score 0.34
fat body mass · score 0.34
Barrett's esophagus · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12946-F1	alphafold	PREDICTED	57.78	—

Amino-acid sequence (379 residues)

MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP YSYIALIVMA IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS CPPNSLALEG GLGMMNGHLP GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD SSVPASPLLP TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA MASSSMHSAG GGSYYHQQVT YQDIKPCVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards