Forkhead box protein F2 (FOXF2)

About Forkhead box protein F2

Forkhead box protein F2 (FOXF2) is a protein from Homo sapiens identified by UniProt accession Q12947, 444 residues long. MolForge cross-references it against 0 known binders and 211 disease associations.

Target properties

Protein name	Forkhead box protein F2
UniProt accession	Q12947
Gene	FOXF2
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (211)

Diseases linked to this target (Open Targets).

Ischemic stroke · score 0.36
balding measurement · score 0.34
stroke · score 0.33
testosterone measurement · score 0.30
protein measurement · score 0.29
retinal vasculature measurement · score 0.27
puerperal disorder · score 0.16
psoriasis · score 0.15
atopic eczema · score 0.15
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12947-F1	alphafold	PREDICTED	56.43	—

Amino-acid sequence (444 residues)

MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS SSSASCASSS SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK PPYSYIALIV MAIQSSPSKR LTLSEIYQFL QARFPFFRGA YQGWKNSVRH NLSLNECFIK LPKGLGRPGK GHYWTIDPAS EFMFEEGSFR RRPRGFRRKC QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ GGYGGLDMMP AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK QPPALTPSSN PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS TPVCDRKDFV LNFNGISSFH PSASGSYYHH HHQSVCQDIK PCVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards