About Forkhead box protein C1
Forkhead box protein C1 (FOXC1) is a protein
from Homo sapiens identified by UniProt accession
Q12948, 553 residues long.
MolForge cross-references it against 0 known binders and
1,027 disease associations.
Target properties
| Protein name | Forkhead box protein C1 |
|---|
| UniProt accession | Q12948 |
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| Gene | FOXC1 |
|---|
| Organism | Homo sapiens |
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| Length | 553 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1027)
Diseases linked to this target (Open Targets).
- Axenfeld-Rieger syndrome · score 0.76
- Rieger anomaly · score 0.67
- Peters anomaly · score 0.56
- Ocular anterior segment dysgenesis · score 0.46
- anterior segment dysgenesis · score 0.46
- systolic blood pressure · score 0.45
- heel bone mineral density · score 0.44
- open-angle glaucoma · score 0.43
- Axenfeld-Rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities · score 0.43
- glaucoma · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12948-F1 | alphafold | PREDICTED | 54.28 | — |
Amino-acid sequence (553 residues)
MQARYSVSSP NSLGVVPYLG GEQSYYRAAA AAAGGGYTAM PAPMSVYSHP AHAEQYPGGM ARAYGPYTPQ PQPKDMVKPP YSYIALITMA IQNAPDKKIT LNGIYQFIMD RFPFYRDNKQ GWQNSIRHNL SLNECFVKVP RDDKKPGKGS YWTLDPDSYN MFENGSFLRR RRRFKKKDAV KDKEEKDRLH LKEPPPPGRQ PPPAPPEQAD GNAPGPQPPP VRIQDIKTEN GTCPSPPQPL SPAAALGSGS AAAVPKIESP DSSSSSLSSG SSPPGSLPSA RPLSLDGADS APPPPAPSAP PPHHSQGFSV DNIMTSLRGS PQSAAAELSS GLLASAAASS RAGIAPPLAL GAYSPGQSSL YSSPCSQTSS AGSSGGGGGG AGAAGGAGGA GTYHCNLQAM SLYAAGERGG HLQGAPGGAG GSAVDDPLPD YSLPPVTSSS SSSLSHGGGG GGGGGGQEAG HHPAAHQGRL TSWYLNQAGG DLGHLASAAA AAAAAGYPGQ QQNFHSVREM FESQRIGLNN SPVNGNSSCQ MAFPSSQSLY RTSGAFVYDC SKF
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