Forkhead box protein D4 (FOXD4)

About Forkhead box protein D4

Forkhead box protein D4 (FOXD4) is a protein from Homo sapiens identified by UniProt accession Q12950, 439 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Forkhead box protein D4
UniProt accession	Q12950
Gene	FOXD4
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.12
platelet component distribution width · score 0.09
platelet count · score 0.08
Isolated anophthalmia - microphthalmia · score 0.05
Microphthalmia - ankyloblepharon - intellectual disability · score 0.05
monocyte percentage of leukocytes · score 0.04
nanophthalmia · score 0.04
microphthalmia · score 0.04
nanophthalmos 2 · score 0.04
Red cell distribution width · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12950-F1	alphafold	PREDICTED	55.68	—

Amino-acid sequence (439 residues)

MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS LQPGLQVARW GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR QPAKPPSSYI ALITMAILQS PHKRLTLSGI CAFISDRFPY YRRKFPAWQN SIRHNLSLND CFVKIPREPG RPGKGNYWSL DPASQDMFDN GSFLRRRKRF QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ PVPGAYPNTG PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP CSSDRQACRT ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA VAEGSGLTSL AAPLGGEGTS PVFLVSPTPS SLAESAGPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards