Forkhead box protein I1 (FOXI1)

About Forkhead box protein I1

Forkhead box protein I1 (FOXI1) is a protein from Homo sapiens identified by UniProt accession Q12951, 378 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.

Target properties

Protein name	Forkhead box protein I1
UniProt accession	Q12951
Gene	FOXI1
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (173)

Diseases linked to this target (Open Targets).

Pendred syndrome · score 0.50
autosomal recessive nonsyndromic hearing loss 4 · score 0.46
hearing loss, autosomal recessive · score 0.41
hearing loss · score 0.37
autosomal recessive distal renal tubular acidosis · score 0.37
Enlarged vestibular aqueduct · score 0.37
Hearing impairment · score 0.30
breast carcinoma · score 0.27
deafness · score 0.20
renal tubular acidosis · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12951-F1	alphafold	PREDICTED	59.08	—

Amino-acid sequence (378 residues)

MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG VPSPQRPSFE GGGEYGATPN PYLWFNGPTM TPPPYLPGPN ASPFLPQAYG VQRPLLPSVS GLGGSDLGWL PIPSQEELMK LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY QYVADNFPFY NKSKAGWQNS IRHNLSLNDC FKKVPRDEDD PGKGNYWTLD PNCEKMFDNG NFRRKRKRKS DVSSSTASLA LEKTESSLPV DSPKTTEPQD ILDGASPGGT TSSPEKRPSP PPSGAPCLNS FLSSMTAYVS GGSPTSHPLV TPGLSPEPSD KTGQNSLTFN SFSPLTNLSN HSGGGDWANP MPTNMLSYGG SVLSQFSPHF YNSVNTSGVL YPREGTEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards