Forkhead box protein L1 (FOXL1)

About Forkhead box protein L1

Forkhead box protein L1 (FOXL1) is a protein from Homo sapiens identified by UniProt accession Q12952, 345 residues long. MolForge cross-references it against 0 known binders and 194 disease associations.

Target properties

Protein name	Forkhead box protein L1
UniProt accession	Q12952
Gene	FOXL1
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (194)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.42
bone density · score 0.40
bone quantitative ultrasound measurement · score 0.38
cortical surface area measurement · score 0.37
colorectal cancer · score 0.36
body height · score 0.36
femoral neck bone mineral density · score 0.34
dentures · score 0.34
appendicular lean mass · score 0.33
sitting height measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12952-F1	alphafold	PREDICTED	62.60	—

Amino-acid sequence (345 residues)

MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNDCFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPGPG APEAKRPRAE THQRSAEAQP EAGSGAGGSG PAISRLQAAP AGPSPLLDGP SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP GSPLRPASRS SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards