Nuclear inhibitor of protein phosphatase 1 (PPP1R8)

About Nuclear inhibitor of protein phosphatase 1

Nuclear inhibitor of protein phosphatase 1 (PPP1R8) is a protein from Homo sapiens identified by UniProt accession Q12972, 351 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Nuclear inhibitor of protein phosphatase 1
UniProt accession	Q12972
Gene	PPP1R8
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
neuroinflammatory disorder · score 0.23
hepatocellular carcinoma · score 0.04
infection · score 0.03
infect · score 0.03
breast cancer · score 0.03
cancer · score 0.02
neutrophil count · score 0.02
neoplasm · score 0.02
axial length measurement · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12972-F1	alphafold	PREDICTED	67.50	—

Amino-acid sequence (351 residues)

MAAAANSGSS LPLFDCPTWA GKPPPGLHLD VVKGDKLIEK LIIDEKKYYL FGRNPDLCDF TIDHQSCSRV HAALVYHKHL KRVFLIDLNS THGTFLGHIR LEPHKPQQIP IDSTVSFGAS TRAYTLREKP QTLPSAVKGD EKMGGEDDEL KGLLGLPEEE TELDNLTEFN TAHNKRISTL TIEEGNLDIQ RPKRKRKNSR VTFSEDDEII NPEDVDPSVG RFRNMVQTAV VPVKKKRVEG PGSLGLEESG SRRMQNFAFS GGLYGGLPPT HSEAGSQPHG IHGTALIGGL PMPYPNLAPD VDLTPVVPSA VNMNPAPNPA VYNPEAVNEP KKKKYAKEAW PGKKPTPSLL I

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards