Protein tyrosine phosphatase type IVA 2 (PTP4A2)

About Protein tyrosine phosphatase type IVA 2

Protein tyrosine phosphatase type IVA 2 (PTP4A2) is a protein from Homo sapiens identified by UniProt accession Q12974, 167 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	Protein tyrosine phosphatase type IVA 2
UniProt accession	Q12974
Gene	PTP4A2
Organism	Homo sapiens
Length	167 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (97)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
body height · score 0.29
appendicular lean mass · score 0.27
lean body mass · score 0.22
neuroinflammatory disorder · score 0.22
sitting height measurement · score 0.20
fat body mass · score 0.17
whole body water mass · score 0.16
forced expiratory volume · score 0.15
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12974-F1	alphafold	PREDICTED	90.43	—

Amino-acid sequence (167 residues)

MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR PKMRLRFRDT NGHCCVQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards