About GATOR1 complex protein NPRL3
GATOR1 complex protein NPRL3 (NPRL3) is a protein
from Homo sapiens identified by UniProt accession
Q12980, 569 residues long.
MolForge cross-references it against 0 known binders and
162 disease associations.
Target properties
| Protein name | GATOR1 complex protein NPRL3 |
|---|
| UniProt accession | Q12980 |
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| Gene | NPRL3 |
|---|
| Organism | Homo sapiens |
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| Length | 569 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (162)
Diseases linked to this target (Open Targets).
- familial focal epilepsy with variable foci · score 0.74
- neurodegenerative disease · score 0.47
- Seizure · score 0.42
- partial epilepsy · score 0.40
- mean corpuscular volume · score 0.31
- mean corpuscular hemoglobin concentration · score 0.30
- mean corpuscular hemoglobin · score 0.29
- erythrocyte count · score 0.27
- Intellectual disability · score 0.27
- hemoglobin measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12980-F1 | alphafold | PREDICTED | 66.06 | — |
Amino-acid sequence (569 residues)
MRDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTS KPRSRYAASN TGDHADEQDG DSRFSDVILA TILATKSEMC GQKFELKIDN VRFVGHPTLL QHALGQISKT DPSPKREAPT MILFNVVFAL RANADPSVIN CLHNLSRRIA TVLQHEERRC QYLTREAKLI LALQDEVSAM ADGNEGPQSP FHHILPKCKL ARDLKEAYDS LCTSGVVRLH INSWLEVSFC LPHKIHYAAS SLIPPEAIER SLKAIRPYHA LLLLSDEKSL LGELPIDCSP ALVRVIKTTS AVKNLQQLAQ DADLALLQVF QLAAHLVYWG KAIIIYPLCE NNVYMLSPNA SVCLYSPLAE QFSHQFPSHD LPSVLAKFSL PVSLSEFRNP LAPAVQETQL IQMVVWMLQR RLLIQLHTYV CLMASPSEEE PRPREDDVPF TARVGGRSLS TPNALSFGSP TSSDDMTLTS PSMDNSSAEL LPSGDSPLNQ RMTENLLASL SEHERAAILS VPAAQNPEDL RMFARLLHYF RGRHHLEEIM YNENTRRSQL LMLFDKFRSV LVVTTHEDPV IAVFQALLP
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