About BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is a protein
from Homo sapiens identified by UniProt accession
Q12983, 194 residues long.
MolForge cross-references it against 0 known binders and
352 disease associations.
Target properties
| Protein name | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
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| UniProt accession | Q12983 |
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| Gene | BNIP3 |
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| Organism | Homo sapiens |
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| Length | 194 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (352)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.44
- body height · score 0.32
- self reported educational attainment · score 0.32
- intelligence · score 0.30
- serum urea measurement · score 0.29
- mathematical ability · score 0.28
- mean corpuscular volume · score 0.28
- neutrophil count · score 0.25
- chronotype measurement · score 0.21
- schizophrenia · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12983-F1 | alphafold | PREDICTED | 63.62 | — |
Amino-acid sequence (194 residues)
MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG IYIGRRLTTS TSTF
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