About Heat shock protein beta-3
Heat shock protein beta-3 (HSPB3) is a protein
from Homo sapiens identified by UniProt accession
Q12988, 150 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Heat shock protein beta-3 |
|---|
| UniProt accession | Q12988 |
|---|
| Gene | HSPB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 150 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (135)
Diseases linked to this target (Open Targets).
- distal hereditary motor neuropathy type 2 · score 0.42
- Charcot-Marie-Tooth disease type 2 · score 0.27
- Red cell distribution width · score 0.21
- distal hereditary motor neuropathy · score 0.12
- bladder transitional cell carcinoma · score 0.07
- MODY · score 0.06
- reticulocyte count · score 0.05
- neoplasm · score 0.05
- type 2 diabetes mellitus · score 0.05
- reticulocyte measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12988-F1 | alphafold | PREDICTED | 69.96 | — |
Amino-acid sequence (150 residues)
MAKIILRHLI EIPVRYQEEF EARGLEDCRL DHALYALPGP TIVDLRKTRA AQSPPVDSAA ETPPREGKSH FQILLDVVQF LPEDIIIQTF EGWLLIKAQH GTRMDEHGFI SRSFTRQYKL PDGVEIKDLS AVLCHDGILV VEVKDPVGTK
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