About Tetraspanin-31
Tetraspanin-31 (TSPAN31) is a protein
from Homo sapiens identified by UniProt accession
Q12999, 210 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Tetraspanin-31 |
|---|
| UniProt accession | Q12999 |
|---|
| Gene | TSPAN31 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 210 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- cutaneous melanoma · score 0.21
- familial melanoma · score 0.21
- melanoma, cutaneous malignant, susceptibility to, 3 · score 0.20
- Inherited cancer-predisposing syndrome · score 0.19
- hereditary neoplastic syndrome · score 0.19
- Ewing sarcoma · score 0.12
- diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype · score 0.12
- gonorrhea · score 0.09
- alkaline phosphatase measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12999-F1 | alphafold | PREDICTED | 89.30 | — |
Amino-acid sequence (210 residues)
MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI AVGVFLLLIA VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN RSKQTDVINA SWWVMSNKTR DELERSFDCC GLFNLTTLYQ QDYDFCTAIC KSQSPTCQMC GEKFLKHSDE ALKILGGVGL FFSFTEILGV WLAMRFRNQK DPRANPSAFL
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