About E3 ubiquitin-protein ligase TRIM32
E3 ubiquitin-protein ligase TRIM32 (TRIM32) is a protein
from Homo sapiens identified by UniProt accession
Q13049, 653 residues long.
MolForge cross-references it against 0 known binders and
337 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM32 |
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| UniProt accession | Q13049 |
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| Gene | TRIM32 |
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| Organism | Homo sapiens |
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| Length | 653 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (337)
Diseases linked to this target (Open Targets).
- autosomal recessive limb-girdle muscular dystrophy type 2H · score 0.77
- Bardet-Biedl syndrome 11 · score 0.69
- Bardet-Biedl syndrome · score 0.65
- autosomal recessive limb-girdle muscular dystrophy · score 0.50
- limb-girdle muscular dystrophy · score 0.44
- myopathy · score 0.36
- isolated asymptomatic elevation of creatine phosphokinase · score 0.33
- Elevated circulating creatine kinase concentration · score 0.33
- lean body mass · score 0.26
- osteoarthritis, hip · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13049-F1 | alphafold | PREDICTED | 77.85 | — |
Amino-acid sequence (653 residues)
MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK LLASSINGVR CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC RSCGRRLPRQ FCRSCGLVLC EPCREADHQP PGHCTLPVKE AAEERRRDFG EKLTRLRELM GELQRRKAAL EGVSKDLQAR YKAVLQEYGH EERRVQDELA RSRKFFTGSL AEVEKSNSQV VEEQSYLLNI AEVQAVSRCD YFLAKIKQAD VALLEETADE EEPELTASLP RELTLQDVEL LKVGHVGPLQ IGQAVKKPRT VNVEDSWAME ATASAASTSV TFREMDMSPE EVVASPRASP AKQRGPEAAS NIQQCLFLKK MGAKGSTPGM FNLPVSLYVT SQGEVLVADR GNYRIQVFTR KGFLKEIRRS PSGIDSFVLS FLGADLPNLT PLSVAMNCQG LIGVTDSYDN SLKVYTLDGH CVACHRSQLS KPWGITALPS GQFVVTDVEG GKLWCFTVDR GSGVVKYSCL CSAVRPKFVT CDAEGTVYFT QGLGLNLENR QNEHHLEGGF SIGSVGPDGQ LGRQISHFFS ENEDFRCIAG MCVDARGDLI VADSSRKEIL HFPKGGGYSV LIREGLTCPV GIALTPKGQL LVLDCWDHCI KIYSYHLRRY STP
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