About Bifunctional coenzyme A synthase
Bifunctional coenzyme A synthase (COASY) is a protein
from Homo sapiens identified by UniProt accession
Q13057, 564 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Bifunctional coenzyme A synthase |
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| UniProt accession | Q13057 |
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| Gene | COASY |
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| Organism | Homo sapiens |
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| Length | 564 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- neurodegeneration with brain iron accumulation 6 · score 0.76
- Non-syndromic pontocerebellar hypoplasia · score 0.72
- neurodegeneration with brain iron accumulation · score 0.65
- COASY protein-associated neurodegeneration · score 0.60
- neurodegenerative disease · score 0.56
- lysosomal storage disease · score 0.37
- arthrogryposis · score 0.19
- sex hormone-binding globulin measurement · score 0.15
- IGF-1 measurement · score 0.13
- leukocyte count · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13057-F1 | alphafold | PREDICTED | 89.26 | — |
Amino-acid sequence (564 residues)
MAVFRSGLLV LTTPLASLAP RLASILTSAA RLVNHTLYVH LQPGMSLEGP AQPQSSPVQA TFEVLDFITH LYAGADVHRH LDVRILLTNI RTKSTFLPPL PTSVQNLAHP PEVVLTDFQT LDGSQYNPVK QQLVRYATSC YSCCPRLASV LLYSDYGIGE VPVEPLDVPL PSTIRPASPV AGSPKQPVRG YYRGAVGGTF DRLHNAHKVL LSVACILAQE QLVVGVADKD LLKSKLLPEL LQPYTERVEH LSEFLVDIKP SLTFDVIPLL DPYGPAGSDP SLEFLVVSEE TYRGGMAINR FRLENDLEEL ALYQIQLLKD LRHTENEEDK VSSSSFRQRM LGNLLRPPYE RPELPTCLYV IGLTGISGSG KSSIAQRLKG LGAFVIDSDH LGHRAYAPGG PAYQPVVEAF GTDILHKDGI INRKVLGSRV FGNKKQLKIL TDIMWPIIAK LAREEMDRAV AEGKRVCVID AAVLLEAGWQ NLVHEVWTAV IPETEAVRRI VERDGLSEAA AQSRLQSQMS GQQLVEQSHV VLSTLWEPHI TQRQVEKAWA LLQKRIPKTH QALD
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