E3 ubiquitin-protein ligase makorin-3 (MKRN3)

About E3 ubiquitin-protein ligase makorin-3

E3 ubiquitin-protein ligase makorin-3 (MKRN3) is a protein from Homo sapiens identified by UniProt accession Q13064, 507 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase makorin-3
UniProt accession	Q13064
Gene	MKRN3
Organism	Homo sapiens
Length	507 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

precocious puberty, central, 2 · score 0.68
age at menarche · score 0.41
viral load · score 0.32
body height · score 0.20
genetic disorder · score 0.19
Central precocious puberty · score 0.11
head and neck squamous cell carcinoma · score 0.08
non-small cell lung carcinoma · score 0.08
lung cancer · score 0.07
46,XX gonadal dysgenesis · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13064-F1	alphafold	PREDICTED	62.90	—

Amino-acid sequence (507 residues)

MEEPAAPSEA HEAAGAQAGA EAAREGVSGP DLPVCEPSGE SAAPDSALPH AARGWAPFPV APVPAHLRRG GLRPAPASGG GAWPSPLPSR SSGIWTKQII CRYYIHGQCK EGENCRYSHD LSGRKMATEG GVSPPGASAG GGPSTAAHIE PPTQEVAEAP PAASSLSLPV IGSAAERGFF EAERDNADRG AAGGAGVESW ADAIEFVPGQ PYRGRWVASA PEAPLQSSET ERKQMAVGSG LRFCYYASRG VCFRGESCMY LHGDICDMCG LQTLHPMDAA QREEHMRACI EAHEKDMELS FAVQRGMDKV CGICMEVVYE KANPNDRRFG ILSNCNHSFC IRCIRRWRSA RQFENRIVKS CPQCRVTSEL VIPSEFWVEE EEEKQKLIQQ YKEAMSNKAC RYFAEGRGNC PFGDTCFYKH EYPEGWGDEP PGPGGGSFSA YWHQLVEPVR MGEGNMLYKS IKKELVVLRL ASLLFKRFLS LRDELPFSED QWDLLHYELE EYFNLIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards