TNF receptor-associated factor 1 (TRAF1)

About TNF receptor-associated factor 1

TNF receptor-associated factor 1 (TRAF1) is a protein from Homo sapiens identified by UniProt accession Q13077, 416 residues long. MolForge cross-references it against 0 known binders and 228 disease associations.

Target properties

Protein name	TNF receptor-associated factor 1
UniProt accession	Q13077
Gene	TRAF1
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (228)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.41
cystatin C measurement · score 0.40
lymphocyte count · score 0.39
pulse pressure measurement · score 0.36
leukocyte count · score 0.34
asthma · score 0.34
Eczematoid dermatitis · score 0.33
myeloid white cell count · score 0.32
eosinophil percentage of leukocytes · score 0.27
atopic asthma · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13077-F1	alphafold	PREDICTED	79.23	—

Amino-acid sequence (416 residues)

MASSSGSSPR PAPDENEFPF GCPPTVCQDP KEPRALCCAG CLSENPRNGE DQICPKCRGE DLQSISPGSR LRTQEKAHPE VAEAGIGCPF AGVGCSFKGS PQSVQEHEVT SQTSHLNLLL GFMKQWKARL GCGLESGPMA LEQNLSDLQL QAAVEVAGDL EVDCYRAPCS ESQEELALQH FMKEKLLAEL EGKLRVFENI VAVLNKEVEA SHLALATSIH QSQLDRERIL SLEQRVVELQ QTLAQKDQAL GKLEQSLRLM EEASFDGTFL WKITNVTRRC HESACGRTVS LFSPAFYTAK YGYKLCLRLY LNGDGTGKRT HLSLFIVIMR GEYDALLPWP FRNKVTFMLL DQNNREHAID AFRPDLSSAS FQRPQSETNV ASGCPLFFPL SKLQSPKHAY VKDDTMFLKC IVETST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards