Protein disulfide-isomerase A2 (PDIA2)

About Protein disulfide-isomerase A2

Protein disulfide-isomerase A2 (PDIA2) is a protein from Homo sapiens identified by UniProt accession Q13087, 525 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Protein disulfide-isomerase A2
UniProt accession	Q13087
Gene	PDIA2
Organism	Homo sapiens
Length	525 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.22
mean corpuscular hemoglobin · score 0.21
cardiovascular disease · score 0.20
body fat percentage · score 0.20
mean corpuscular hemoglobin concentration · score 0.19
body mass index · score 0.17
blood pressure · score 0.14
Bicuspid aortic valve · score 0.12
body height · score 0.11
hypertension · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13087-F1	alphafold	PREDICTED	86.70	—

Amino-acid sequence (525 residues)

MSRQLLPVLL LLLLRASCPW GQEQGARSPS EEPPEEEIPK EDGILVLSRH TLGLALREHP ALLVEFYAPW CGHCQALAPE YSKAAAVLAA ESMVVTLAKV DGPAQRELAE EFGVTEYPTL KFFRNGNRTH PEEYTGPRDA EGIAEWLRRR VGPSAMRLED EAAAQALIGG RDLVVIGFFQ DLQDEDVATF LALAQDALDM TFGLTDRPRL FQQFGLTKDT VVLFKKFDEG RADFPVDEEL GLDLGDLSRF LVTHSMRLVT EFNSQTSAKI FAARILNHLL LFVNQTLAAH RELLAGFGEA APRFRGQVLF VVVDVAADNE HVLQYFGLKA EAAPTLRLVN LETTKKYAPV DGGPVTAASI TAFCHAVLNG QVKPYLLSQE IPPDWDQRPV KTLVGKNFEQ VAFDETKNVF VKFYAPWCTH CKEMAPAWEA LAEKYQDHED IIIAELDATA NELDAFAVHG FPTLKYFPAG PGRKVIEYKS TRDLETFSKF LDNGGVLPTE EPPEEPAAPF PEPPANSTMG SKEEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards