About Platelet-activating factor acetylhydrolase
Platelet-activating factor acetylhydrolase (PLA2G7) is a protein
from Homo sapiens identified by UniProt accession
Q13093, 441 residues long.
MolForge cross-references it against 0 known binders and
339 disease associations.
Target properties
| Protein name | Platelet-activating factor acetylhydrolase |
|---|
| UniProt accession | Q13093 |
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| Gene | PLA2G7 |
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| Organism | Homo sapiens |
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| Length | 441 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (339)
Diseases linked to this target (Open Targets).
- Platelet-activating factor acetylhydrolase deficiency · score 0.47
- lipoprotein-associated phospholipase A(2) measurement · score 0.41
- neurodegenerative disease · score 0.32
- atherosclerosis · score 0.31
- response to darapladib · score 0.30
- lipoprotein-associated phospholipase A(2) change measurement · score 0.30
- endothelial dysfunction · score 0.26
- acute coronary syndrome · score 0.26
- cerebrospinal fluid biomarker measurement · score 0.21
- coronary artery disease · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13093-F1 | alphafold | PREDICTED | 87.82 | — |
Amino-acid sequence (441 residues)
MVPPKLHVLF CLCGCLAVVY PFDWQYINPV AHMKSSAWVN KIQVLMAAAS FGQTKIPRGN GPYSVGCTDL MFDHTNKGTF LRLYYPSQDN DRLDTLWIPN KEYFWGLSKF LGTHWLMGNI LRLLFGSMTT PANWNSPLRP GEKYPLVVFS HGLGAFRTLY SAIGIDLASH GFIVAAVEHR DRSASATYYF KDQSAAEIGD KSWLYLRTLK QEEETHIRNE QVRQRAKECS QALSLILDID HGKPVKNALD LKFDMEQLKD SIDREKIAVI GHSFGGATVI QTLSEDQRFR CGIALDAWMF PLGDEVYSRI PQPLFFINSE YFQYPANIIK MKKCYSPDKE RKMITIRGSV HQNFADFTFA TGKIIGHMLK LKGDIDSNVA IDLSNKASLA FLQKHLGLHK DFDQWDCLIE GDDENLIPGT NINTTNQHIM LQNSSGIEKY N
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