About Intraflagellar transport protein 88 homolog
Intraflagellar transport protein 88 homolog (IFT88) is a protein
from Homo sapiens identified by UniProt accession
Q13099, 824 residues long.
MolForge cross-references it against 0 known binders and
377 disease associations.
Target properties
| Protein name | Intraflagellar transport protein 88 homolog |
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| UniProt accession | Q13099 |
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| Gene | IFT88 |
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| Organism | Homo sapiens |
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| Length | 824 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (377)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.37
- Cone rod dystrophy · score 0.30
- blood protein measurement · score 0.19
- self reported educational attainment · score 0.19
- Jeune syndrome · score 0.11
- hepatocellular carcinoma · score 0.09
- Syndactyly type 2 · score 0.09
- syndactyly type 4 · score 0.08
- polydactyly of a triphalangeal thumb · score 0.08
- Triphalangeal thumb - polysyndactyly syndrome · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13099-F1 | alphafold | PREDICTED | 76.35 | — |
Amino-acid sequence (824 residues)
MMQNVHLAPE TDEDDLYSGY NDYNPIYDIE ELENDAAFQQ AVRTSHGRRP PITAKISSTA VTRPIATGYG SKTSLASSIG RPMTGAIQDG VTRPMTAVRA AGFTKAALRG SAFDPLSQSR GPASPLEAKK KDSPEEKIKQ LEKEVNELVE ESCIANSCGD LKLALEKAKD AGRKERVLVR QREQVTTPEN INLDLTYSVL FNLASQYSVN EMYAEALNTY QVIVKNKMFS NAGILKMNMG NIYLKQRNYS KAIKFYRMAL DQVPSVNKQM RIKIMQNIGV TFIQAGQYSD AINSYEHIMS MAPNLKAGYN LTICYFAIGD REKMKKAFQK LITVPLEIDE DKYISPSDDP HTNLVTEAIK NDHLRQMERE RKAMAEKYIM TSAKLIAPVI ETSFAAGYDW CVEVVKASQY VELANDLEIN KAVTYLRQKD YNQAVEILKV LEKKDSRVKS AAATNLSALY YMGKDFAQAS SYADIAVNSD RYNPAALTNK GNTVFANGDY EKAAEFYKEA LRNDSSCTEA LYNIGLTYEK LNRLDEALDC FLKLHAILRN SAEVLYQIAN IYELMENPSQ AIEWLMQVVS VIPTDPQVLS KLGELYDREG DKSQAFQYYY ESYRYFPCNI EVIEWLGAYY IDTQFWEKAI QYFERASLIQ PTQVKWQLMV ASCFRRSGNY QKALDTYKDT HRKFPENVEC LRFLVRLCTD LGLKDAQEYA RKLKRLEKMK EIREQRIKSG RDGSGGSRGK REGSASGDSG QNYSASSKGE RLSARLRALP GTNEPYESSS NKEIDASYVD PLGPQIERPK TAAKKRIDED DFADEELGDD LLPE
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