About Chromatin assembly factor 1 subunit B
Chromatin assembly factor 1 subunit B (CHAF1B) is a protein
from Homo sapiens identified by UniProt accession
Q13112, 559 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Chromatin assembly factor 1 subunit B |
|---|
| UniProt accession | Q13112 |
|---|
| Gene | CHAF1B |
|---|
| Organism | Homo sapiens |
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| Length | 559 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (109)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.27
- heel bone mineral density · score 0.26
- Intellectual disability · score 0.26
- attention deficit hyperactivity disorder · score 0.26
- Global developmental delay · score 0.26
- serum urea measurement · score 0.24
- eosinophil count · score 0.23
- hemoglobin measurement · score 0.18
- nephrolithiasis · score 0.18
- erythrocyte count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13112-F1 | alphafold | PREDICTED | 74.75 | — |
Amino-acid sequence (559 residues)
MKVITCEIAW HNKEPVYSLD FQHGTAGRIH RLASAGVDTN VRIWKVEKGP DGKAIVEFLS NLARHTKAVN VVRFSPTGEI LASGGDDAVI LLWKVNDNKE PEQIAFQDED EAQLNKENWT VVKTLRGHLE DVYDICWATD GNLMASASVD NTAIIWDVSK GQKISIFNEH KSYVQGVTWD PLGQYVATLS CDRVLRVYSI QKKRVAFNVS KMLSGIGAEG EARSYRMFHD DSMKSFFRRL SFTPDGSLLL TPAGCVESGE NVMNTTYVFS RKNLKRPIAH LPCPGKATLA VRCCPVYFEL RPVVETGVEL MSLPYRLVFA VASEDSVLLY DTQQSFPFGY VSNIHYHTLS DISWSSDGAF LAISSTDGYC SFVTFEKDEL GIPLKEKPVL NMRTPDTAKK TKSQTHRGSS PGPRPVEGTP ASRTQDPSSP GTTPPQARQA PAPTVIRDPP SITPAVKSPL PGPSEEKTLQ PSSQNTKAHP SRRVTLNTLQ AWSKTTPRRI NLTPLKTDTP PSSVPTSVIS TPSTEEIQSE TPGDAQGSPP ELKRPRLDEN KGGTESLDP
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