About TNF receptor-associated factor 3
TNF receptor-associated factor 3 (TRAF3) is a protein
from Homo sapiens identified by UniProt accession
Q13114, 568 residues long.
MolForge cross-references it against 0 known binders and
348 disease associations.
Target properties
| Protein name | TNF receptor-associated factor 3 |
|---|
| UniProt accession | Q13114 |
|---|
| Gene | TRAF3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 568 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (348)
Diseases linked to this target (Open Targets).
- Herpetic encephalitis · score 0.46
- body mass index · score 0.45
- lean body mass · score 0.42
- total blood protein measurement · score 0.42
- body fat percentage · score 0.39
- high density lipoprotein cholesterol measurement · score 0.39
- monocyte count · score 0.39
- TRAF3 haploinsufficiency · score 0.39
- inborn error of immunity · score 0.38
- Eczematoid dermatitis · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13114-F1 | alphafold | PREDICTED | 87.88 | — |
Amino-acid sequence (568 residues)
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV FKDNCCKREI LALQIYCRNE SRGCAEQLML GHLLVHLKND CHFEELPCVR PDCKEKVLRK DLRDHVEKAC KYREATCSHC KSQVPMIALQ KHEDTDCPCV VVSCPHKCSV QTLLRSELSA HLSECVNAPS TCSFKRYGCV FQGTNQQIKA HEASSAVQHV NLLKEWSNSL EKKVSLLQNE SVEKNKSIQS LHNQICSFEI EIERQKEMLR NNESKILHLQ RVIDSQAEKL KELDKEIRPF RQNWEEADSM KSSVESLQNR VTELESVDKS AGQVARNTGL LESQLSRHDQ MLSVHDIRLA DMDLRFQVLE TASYNGVLIW KIRDYKRRKQ EAVMGKTLSL YSQPFYTGYF GYKMCARVYL NGDGMGKGTH LSLFFVIMRG EYDALLPWPF KQKVTLMLMD QGSSRRHLGD AFKPDPNSSS FKKPTGEMNI ASGCPVFVAQ TVLENGTYIK DDTIFIKVIV DTSDLPDP
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