Dual specificity protein phosphatase 4 (DUSP4)

About Dual specificity protein phosphatase 4

Dual specificity protein phosphatase 4 (DUSP4) is a protein from Homo sapiens identified by UniProt accession Q13115, 394 residues long. MolForge cross-references it against 0 known binders and 776 disease associations.

Target properties

Protein name	Dual specificity protein phosphatase 4
UniProt accession	Q13115
Gene	DUSP4
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (776)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
heel bone mineral density · score 0.35
protein measurement · score 0.29
breast adenocarcinoma · score 0.29
high density lipoprotein cholesterol measurement · score 0.26
response to statin · score 0.26
body height · score 0.26
BMI-adjusted waist circumference · score 0.25
mammographic density percentage · score 0.19
cutaneous melanoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13115-F1	alphafold	PREDICTED	77.12	—

Amino-acid sequence (394 residues)

MVTMEELREM DCSVLKRLMN RDENGGGAGG SGSHGTLGLP SGGKCLLLDC RPFLAHSAGY ILGSVNVRCN TIVRRRAKGS VSLEQILPAE EEVRARLRSG LYSAVIVYDE RSPRAESLRE DSTVSLVVQA LRRNAERTDI CLLKGGYERF SSEYPEFCSK TKALAAIPPP VPPSATEPLD LGCSSCGTPL HDQGGPVEIL PFLYLGSAYH AARRDMLDAL GITALLNVSS DCPNHFEGHY QYKCIPVEDN HKADISSWFM EAIEYIDAVK DCRGRVLVHC QAGISRSATI CLAYLMMKKR VRLEEAFEFV KQRRSIISPN FSFMGQLLQF ESQVLATSCA AEAASPSGPL RERGKTPATP TSQFVFSFPV SVGVHSAPSS LPYLHSPITT SPSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards