Krueppel-like factor 10 (KLF10)

About Krueppel-like factor 10

Krueppel-like factor 10 (KLF10) is a protein from Homo sapiens identified by UniProt accession Q13118, 480 residues long. MolForge cross-references it against 0 known binders and 247 disease associations.

Target properties

Protein name	Krueppel-like factor 10
UniProt accession	Q13118
Gene	KLF10
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (247)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
serum alanine aminotransferase measurement · score 0.42
urate measurement · score 0.39
mean reticulocyte volume · score 0.37
mean corpuscular volume · score 0.37
C-reactive protein measurement · score 0.37
age at menopause · score 0.34
uric acid measurement · score 0.27
schizophrenia · score 0.21
body height · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13118-F1	alphafold	PREDICTED	49.85	—

Amino-acid sequence (480 residues)

MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC SWKSDFKKYV ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD FEPSQVSNLM APAPSTVHFK SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA QATSVIRHTA DAQLCNHQTC PMKAASILNY QNNSFRRRTH LNVEAARKNI PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI CRSQPAPVSP QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF SPSAAKVTPQ IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards