S-methyl-5'-thioadenosine phosphorylase (MTAP)

About S-methyl-5'-thioadenosine phosphorylase

S-methyl-5'-thioadenosine phosphorylase (MTAP) is a protein from Homo sapiens identified by UniProt accession Q13126, 283 residues long. MolForge cross-references it against 0 known binders and 339 disease associations.

Target properties

Protein name	S-methyl-5'-thioadenosine phosphorylase
UniProt accession	Q13126
Gene	MTAP
Organism	Homo sapiens
Length	283 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (339)

Diseases linked to this target (Open Targets).

Diaphyseal medullary stenosis - bone malignancy · score 0.64
diaphyseal medullary stenosis-bone malignancy syndrome · score 0.62
cutaneous melanoma · score 0.42
nevus count · score 0.40
diastolic blood pressure · score 0.37
lung adenocarcinoma · score 0.33
melanoma · score 0.32
coronary artery disease · score 0.31
non-small cell lung carcinoma · score 0.29
total blood protein measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13126-F1	alphafold	PREDICTED	92.71	—

Amino-acid sequence (283 residues)

MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards