About Oxysterols receptor LXR-alpha
Oxysterols receptor LXR-alpha (NR1H3) is a protein
from Homo sapiens identified by UniProt accession
Q13133, 447 residues long.
MolForge cross-references it against 0 known binders and
413 disease associations.
Target properties
| Protein name | Oxysterols receptor LXR-alpha |
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| UniProt accession | Q13133 |
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| Gene | NR1H3 |
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| Organism | Homo sapiens |
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| Length | 447 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (413)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.64
- triglyceride:HDL cholesterol ratio · score 0.38
- multiple sclerosis · score 0.34
- cholesterol to total lipids in medium HDL percentage · score 0.34
- lipoprotein measurement · score 0.34
- cholesterol to total lipids in large HDL percentage · score 0.31
- cholesteryl esters to total lipids in large HDL percentage · score 0.30
- phospholipids:total lipids ratio · score 0.29
- monocyte count · score 0.28
- serum urea measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13133-F1 | alphafold | PREDICTED | 80.66 | — |
Amino-acid sequence (447 residues)
MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM APDPHSREAR QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE
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