About Calcium-binding and coiled-coil domain-containing protein 2
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) is a protein
from Homo sapiens identified by UniProt accession
Q13137, 446 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Calcium-binding and coiled-coil domain-containing protein 2 |
|---|
| UniProt accession | Q13137 |
|---|
| Gene | CALCOCO2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 446 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.28
- blood protein measurement · score 0.25
- appendicular lean mass · score 0.25
- chronotype measurement · score 0.17
- lean body mass · score 0.13
- whole body water mass · score 0.10
- fat body mass · score 0.09
- neutrophil count · score 0.09
- eosinophil count · score 0.05
- platelet count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13137-F1 | alphafold | PREDICTED | 80.20 | — |
Amino-acid sequence (446 residues)
MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYIPGGDVTC HYTFTQHFIP RRKDWIGIFR VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK DDEYYQFCYV DEDGVVRGAS IPFQFRPENE EDILVVTTQG EVEEIEQHNK ELCKENQELK DSCISLQKQN SDMQAELQKK QEELETLQSI NKKLELKVKE QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ EKEMEKLVQG DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ QELMDENFDL SKRLSENEII CNALQRQKER LEGENDLLKR ENSRLLSYMG LDFNSLPYQV PTSDEGGARQ NPGLAYGNPY SGIQESSSPS PLSIKKCPIC KADDICDHTL EQQQMQPLCF NCPICDKIFP ATEKQIFEDH VFCHSL
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