About Translation initiation factor eIF2B subunit epsilon
Translation initiation factor eIF2B subunit epsilon (EIF2B5) is a protein
from Homo sapiens identified by UniProt accession
Q13144, 721 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Translation initiation factor eIF2B subunit epsilon |
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| UniProt accession | Q13144 |
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| Gene | EIF2B5 |
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| Organism | Homo sapiens |
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| Length | 721 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- CACH syndrome · score 0.70
- ovarioleukodystrophy · score 0.64
- leukoencephalopathy with vanishing white matter 1 · score 0.63
- leukoencephalopathy with vanishing white matter · score 0.56
- genetic disorder · score 0.47
- late infantile CACH syndrome · score 0.37
- juvenile or adult CACH syndrome · score 0.37
- congenital or early infantile CACH syndrome · score 0.37
- leukodystrophy · score 0.34
- Developmental regression · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13144-F1 | alphafold | PREDICTED | 78.75 | — |
Amino-acid sequence (721 residues)
MAAPVVAPPG VVVSRANKRS GAGPGGSGGG GARGAEEEPP PPLQAVLVAD SFDRRFFPIS KDQPRVLLPL ANVALIDYTL EFLTATGVQE TFVFCCWKAA QIKEHLLKSK WCRPTSLNVV RIITSELYRS LGDVLRDVDA KALVRSDFLL VYGDVISNIN ITRALEEHRL RRKLEKNVSV MTMIFKESSP SHPTRCHEDN VVVAVDSTTN RVLHFQKTQG LRRFAFPLSL FQGSSDGVEV RYDLLDCHIS ICSPQVAQLF TDNFDYQTRD DFVRGLLVNE EILGNQIHMH VTAKEYGARV SNLHMYSAVC ADVIRRWVYP LTPEANFTDS TTQSCTHSRH NIYRGPEVSL GHGSILEENV LLGSGTVIGS NCFITNSVIG PGCHIGDNVV LDQTYLWQGV RVAAGAQIHQ SLLCDNAEVK ERVTLKPRSV LTSQVVVGPN ITLPEGSVIS LHPPDAEEDE DDGEFSDDSG ADQEKDKVKM KGYNPAEVGA AGKGYLWKAA GMNMEEEEEL QQNLWGLKIN MEEESESESE QSMDSEEPDS RGGSPQMDDI KVFQNEVLGT LQRGKEENIS CDNLVLEINS LKYAYNISLK EVMQVLSHVV LEFPLQQMDS PLDSSRYCAL LLPLLKAWSP VFRNYIKRAA DHLEALAAIE DFFLEHEALG ISMAKVLMAF YQLEILAEET ILSWFSQRDT TDKGQQLRKN QQLQRFIQWL KEAEEESSED D
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