About TAR DNA-binding protein 43
TAR DNA-binding protein 43 (TARDBP) is a protein
from Homo sapiens identified by UniProt accession
Q13148, 414 residues long.
MolForge cross-references it against 0 known binders and
548 disease associations.
Target properties
| Protein name | TAR DNA-binding protein 43 |
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| UniProt accession | Q13148 |
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| Gene | TARDBP |
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| Organism | Homo sapiens |
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| Length | 414 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (548)
Diseases linked to this target (Open Targets).
- familial amyotrophic lateral sclerosis · score 0.83
- amyotrophic lateral sclerosis · score 0.70
- frontotemporal dementia with motor neuron disease · score 0.70
- GRN-related frontotemporal lobar degeneration with Tdp43 inclusions · score 0.55
- frontotemporal dementia · score 0.46
- motor neuron disease · score 0.44
- neurodegenerative disease · score 0.44
- Amyotrophic lateral sclerosis · score 0.39
- Frontotemporal dementia · score 0.38
- immunodeficiency due to MASP-2 deficiency · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13148-F1 | alphafold | PREDICTED | 65.17 | — |
Amino-acid sequence (414 residues)
MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM
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