About Serine/threonine-protein kinase PAK 1
Serine/threonine-protein kinase PAK 1 (PAK1) is a protein
from Homo sapiens identified by UniProt accession
Q13153, 545 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase PAK 1 |
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| UniProt accession | Q13153 |
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| Gene | PAK1 |
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| Organism | Homo sapiens |
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| Length | 545 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (186)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with macrocephaly, seizures, and speech delay · score 0.67
- Neurodevelopmental disorder · score 0.48
- genetic disorder · score 0.33
- body fat percentage · score 0.33
- fat body mass · score 0.33
- breast adenocarcinoma · score 0.28
- cutaneous melanoma · score 0.27
- endometrial cancer · score 0.27
- lung adenocarcinoma · score 0.26
- head and neck squamous cell carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13153-F1 | alphafold | PREDICTED | 73.67 | — |
Amino-acid sequence (545 residues)
MSNNGLDIQD KPPAPPMRNT STMIGAGSKD AGTLNHGSKP LPPNPEEKKK KDRFYRSILP GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNALN VKAVSETPAV PPVSEDEDDD DDDATPPPVI APRPEHTKSV YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE KQKKKPKMSD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAMDV ATGQEVAIKQ MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG SLTDVVTETC MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD GSVKLTDFGF CAQITPEQSK RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL GIMAIEMIEG EPPYLNENPL RALYLIATNG TPELQNPEKL SAIFRDFLNR CLEMDVEKRG SAKELLQHQF LKIAKPLSSL TPLIAAAKEA TKNNH
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