About Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) is a protein
from Homo sapiens identified by UniProt accession
Q13155, 320 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
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| UniProt accession | Q13155 |
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| Gene | AIMP2 |
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| Organism | Homo sapiens |
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| Length | 320 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- leukodystrophy, hypomyelinating, 17 · score 0.59
- genetic disorder · score 0.49
- reticulocyte count · score 0.29
- reticulocyte measurement · score 0.26
- West syndrome · score 0.18
- Epileptic encephalopathy · score 0.18
- Neurodevelopmental abnormality · score 0.11
- cancer · score 0.10
- neoplasm · score 0.09
- acute myeloid leukemia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13155-F1 | alphafold | PREDICTED | 81.14 | — |
Amino-acid sequence (320 residues)
MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL SLQALESRQD DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT LTTNALDLNS VLGKDYGALK DIVINANPAS PPLSLLVLHR LLCEHFRVLS TVHTHSSVKS VPENLLKCFG EQNKKQPRQD YQLGFTLIWK NVPKTQMKFS IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA IFQLKEGSSK EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ RWMRSCENLA PFNTALKLLK
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