About Replication protein A 30 kDa subunit
Replication protein A 30 kDa subunit (RPA4) is a protein
from Homo sapiens identified by UniProt accession
Q13156, 261 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Replication protein A 30 kDa subunit |
|---|
| UniProt accession | Q13156 |
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| Gene | RPA4 |
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| Organism | Homo sapiens |
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| Length | 261 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- endometrial cancer · score 0.18
- actinic keratosis · score 0.04
- non-small cell lung carcinoma · score 0.03
- gonorrhea · score 0.02
- bacteriemia · score 0.01
- neoplasm · score 0.01
- retinoblastoma · score 0.01
- spinocerebellar ataxia type 1 · score 0.00
- pancreatic carcinoma · score 0.00
- lung adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13156-F1 | alphafold | PREDICTED | 80.68 | — |
Amino-acid sequence (261 residues)
MSKSGFGSYG SISAADGASG GSDQLCERDA TPAIKTQRPK VRIQDVVPCN VNQLLSSTVF DPVFKVRGII VSQVSIVGVI RGAEKASNHI CYKIDDMTAK PIEARQWFGR EKVKQVTPLS VGVYVKVFGI LKCPTGTKSL EVLKIHVLED MNEFTVHILE TVNAHMMLDK ARRDTTVESV PVSPSEVNDA GDNDESHRNF IQDEVLRLIH ECPHQEGKSI HELRAQLCDL SVKAIKEAID YLTVEGHIYP TVDREHFKSA D
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