About FAS-associated death domain protein
FAS-associated death domain protein (FADD) is a protein
from Homo sapiens identified by UniProt accession
Q13158, 208 residues long.
MolForge cross-references it against 0 known binders and
370 disease associations.
Target properties
| Protein name | FAS-associated death domain protein |
|---|
| UniProt accession | Q13158 |
|---|
| Gene | FADD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 208 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (370)
Diseases linked to this target (Open Targets).
- FADD-related immunodeficiency · score 0.68
- Abnormal cardiovascular system morphology · score 0.46
- genetic disorder · score 0.41
- head and neck squamous cell carcinoma · score 0.32
- lung adenocarcinoma · score 0.29
- breast adenocarcinoma · score 0.24
- ovarian cancer · score 0.23
- cutaneous melanoma · score 0.22
- gastric adenocarcinoma · score 0.21
- FEV/FVC ratio · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13158-F1 | alphafold | PREDICTED | 72.10 | — |
Amino-acid sequence (208 residues)
MDPFLVLLHS VSSSLSSSEL TELKFLCLGR VGKRKLERVQ SGLDLFSMLL EQNDLEPGHT ELLRELLASL RRHDLLRRVD DFEAGAAAGA APGEEDLCAA FNVICDNVGK DWRRLARQLK VSDTKIDSIE DRYPRNLTER VRESLRIWKN TEKENATVAH LVGALRSCQM NLVADLVQEV QQARDLQNRS GAMSPMSWNS DASTSEAS
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