About Dual specificity mitogen-activated protein kinase kinase 5
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) is a protein
from Homo sapiens identified by UniProt accession
Q13163, 448 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Dual specificity mitogen-activated protein kinase kinase 5 |
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| UniProt accession | Q13163 |
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| Gene | MAP2K5 |
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| Organism | Homo sapiens |
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| Length | 448 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (140)
Diseases linked to this target (Open Targets).
- body mass index · score 0.37
- body fat percentage · score 0.36
- lean body mass · score 0.35
- waist circumference · score 0.30
- fat body mass · score 0.30
- visceral adipose tissue measurement · score 0.26
- age at menarche · score 0.25
- thyroid gland adenocarcinoma · score 0.23
- body weight · score 0.23
- diastolic blood pressure · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13163-F1 | alphafold | PREDICTED | 78.48 | — |
Amino-acid sequence (448 residues)
MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC TEFMDGGSLD VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV QFNDGNAAVV SMWVCRALEE RRSQQGPP
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