About Mitogen-activated protein kinase 7
Mitogen-activated protein kinase 7 (MAPK7) is a protein
from Homo sapiens identified by UniProt accession
Q13164, 816 residues long.
MolForge cross-references it against 0 known binders and
310 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase 7 |
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| UniProt accession | Q13164 |
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| Gene | MAPK7 |
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| Organism | Homo sapiens |
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| Length | 816 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (310)
Diseases linked to this target (Open Targets).
- low grade glioma · score 0.23
- lymphocyte count · score 0.20
- glioblastoma multiforme · score 0.19
- diastolic blood pressure · score 0.17
- cortical thickness · score 0.13
- white matter hyperintensity measurement · score 0.12
- endometrial cancer · score 0.12
- neoplasm · score 0.11
- cancer · score 0.11
- head and neck squamous cell carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13164-F1 | alphafold | PREDICTED | 65.06 | — |
Amino-acid sequence (816 residues)
MAEPLKEEDG EDGSAEPPGP VKAEPAHTAA SVAAKNLALL KARSFDVTFD VGDEYEIIET IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL RELKILKHFK HDNIIAIKDI LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH RDLKPSNLLV NENCELKIGD FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT QAIDLWSVGC IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY HDPDDEPDCA PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR FQPSLQPVAS EPGCPDVEMP SPWAPSGDCA MESPPPAPPP CPGPAPDTID LTLQPPPPVS EPAPPKKDGA ISDNTKAALK AALLKSLRSR LRDGPSAPLE APEPRKPVTA QERQREREEK RRRRQERAKE REKRRQERER KERGAGASGG PSTDPLAGLV LSDNDRSLLE RWTRMARPAA PALTSVPAPA PAPTPTPTPV QPTSPPPGPV AQPTGPQPQS AGSTSGPVPQ PACPPPGPAP HPTGPPGPIP VPAPPQIATS TSLLAAQSLV PPPGLPGSST PGVLPYFPPG LPPPDAGGAP QSSMSESPDV NLVTQQLSKS QVEDPLPPVF SGTPKGSGAG YGVGFDLEEF LNQSFDMGVA DGPQDGQADS ASLSASLLAD WLEGHGMNPA DIESLQREIQ MDSPMLLADL PDLQDP
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