About Serine/threonine-protein kinase PAK 2
Serine/threonine-protein kinase PAK 2 (PAK2) is a protein
from Homo sapiens identified by UniProt accession
Q13177, 524 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase PAK 2 |
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| UniProt accession | Q13177 |
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| Gene | PAK2 |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (142)
Diseases linked to this target (Open Targets).
- Knobloch syndrome · score 0.45
- lymphocyte count · score 0.44
- platelet count · score 0.43
- neutrophil count · score 0.43
- leukocyte count · score 0.43
- monocyte count · score 0.43
- Red cell distribution width · score 0.40
- eosinophil count · score 0.39
- mean corpuscular volume · score 0.39
- platelet crit · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13177-F1 | alphafold | PREDICTED | 74.62 | — |
Amino-acid sequence (524 residues)
MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR
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