About Dual specificity protein phosphatase 8
Dual specificity protein phosphatase 8 (DUSP8) is a protein
from Homo sapiens identified by UniProt accession
Q13202, 625 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Dual specificity protein phosphatase 8 |
|---|
| UniProt accession | Q13202 |
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| Gene | DUSP8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 625 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- thyroid gland adenocarcinoma · score 0.30
- glioblastoma multiforme · score 0.30
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.18
- endometrial cancer · score 0.18
- insulin like growth factor measurement · score 0.17
- brain volume measurement · score 0.10
- neuroimaging measurement · score 0.08
- body height · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13202-F1 | alphafold | PREDICTED | 62.77 | — |
Amino-acid sequence (625 residues)
MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS WHVLSSVNIC CSKLVKRRLQ QGKVTIAELI QPAARSQVEA TEPQDVVVYD QSTRDASVLA ADSFLSILLS KLDGCFDSVA ILTGGFATFS SCFPGLCEGK PAALLPMSLS QPCLPVPSVG LTRILPHLYL GSQKDVLNKD LMTQNGISYV LNASNSCPKP DFICESRFMR VPINDNYCEK LLPWLDKSIE FIDKAKLSSC QVIVHCLAGI SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL KLLAALQGDP GTPSGTPEPP PSPAAGAPLP RLPPPTSESA ATGNAAAREG GLSAGGEPPA PPTPPATSAL QQGLRGLHLS SDRLQDTNRL KRSFSLDIKS AYAPSRRPDG PGPPDPGEAP KLCKLDSPSG AALGLSSPSP DSPDAAPEAR PRPRRRPRPP AGSPARSPAH SLGLNFGDAA RQTPRHGLSA LSAPGLPGPG QPAGPGAWAP PLDSPGTPSP DGPWCFSPEG AQGAGGVLFA PFGRAGAPGP GGGSDLRRRE AARAEPRDAR TGWPEEPAPE TQFKRRSCQM EFEEGMVEGR ARGEELAALG KQASFSGSVE VIEVS
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