Myosin-binding protein H (MYBPH)

About Myosin-binding protein H

Myosin-binding protein H (MYBPH) is a protein from Homo sapiens identified by UniProt accession Q13203, 477 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Myosin-binding protein H
UniProt accession	Q13203
Gene	MYBPH
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
diastolic blood pressure · score 0.20
YKL40 measurement · score 0.15
blood protein measurement · score 0.15
systolic blood pressure · score 0.15
drug use measurement · score 0.14
asthma · score 0.06
eosinophil count · score 0.06
osteoporosis · score 0.05
Osteoporosis · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13203-F1	alphafold	PREDICTED	84.21	—

Amino-acid sequence (477 residues)

MMEKNTSEGP ACSPEETASE SAKVPTAEPP GEVAVSESTR EEQVPKPQAP APQAPTASTA TKPAPPSEDV PSAPLLLTLD DVSSSSVTVS WEPPERLGRL GLQGYVLELC REGASEWVPV SARPMMVTQQ TVRNLALGDK FLLRVSAVSS AGAGPPAMLD QPIHIRENIE APKIRVPRHL RQTYIRQVGE TVNLQIPFQG KPKPQATWTH NGHALDSQRV SMRTGDQDSI LFIRSAQRSD SGRYELTVRV EDLEAKAVID ILVIEKPGPP SSIRLLDVWG CNAALQWTPP QDTGNTELLG YMVQKADKKT GQWFTVLERY HPTTCTISDL IIGNSYSFRV FSENLCGLST SATVTKELAH IQKADIAAKP KGFIERDFSE APSFTQPLAD HTSTPGYSTQ LFCSVRASPK PKIIWMKNKM EIQGNPKYRA LSEQGVCTLE IRKPSPFDSG VYTCKAINVL GEASVDCRLE VKASAAH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards