About Probable ATP-dependent RNA helicase DDX10
Probable ATP-dependent RNA helicase DDX10 (DDX10) is a protein
from Homo sapiens identified by UniProt accession
Q13206, 875 residues long.
MolForge cross-references it against 0 known binders and
123 disease associations.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX10 |
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| UniProt accession | Q13206 |
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| Gene | DDX10 |
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| Organism | Homo sapiens |
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| Length | 875 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (123)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- lymphoid neoplasm · score 0.37
- bile duct carcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
- gastric carcinoma · score 0.37
- prostate adenocarcinoma · score 0.37
- Hepatobiliary Neoplasm · score 0.37
- esophageal adenocarcinoma · score 0.37
- kidney neoplasm · score 0.37
- HER2 Positive Breast Carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13206-F1 | alphafold | PREDICTED | 70.68 | — |
Amino-acid sequence (875 residues)
MGKTANSPGS GARPDPVRSF NRWKKKHSHR QNKKKQLRKQ LKKPEWQVER ESISRLMQNY EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI GLALQGKDVL GAAKTGSGKT LAFLVPVLEA LYRLQWTSTD GLGVLIISPT RELAYQTFEV LRKVGKNHDF SAGLIIGGKD LKHEAERINN INILVCTPGR LLQHMDETVS FHATDLQMLV LDEADRILDM GFADTMNAVI ENLPKKRQTL LFSATQTKSV KDLARLSLKN PEYVWVHEKA KYSTPATLEQ NYIVCELQQK ISVLYSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGV SILALHGRQQ QMRRMEVYNE FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI HRAGRTARYK EDGEALLILL PSEKAMVQQL LQKKVPVKEI KINPEKLIDV QKKLESILAQ DQDLKERAQR CFVSYVRSVY LMKDKEVFDV SKLPIPEYAL SLGLAVAPRV RFLQKMQKQP TKELVRSQAD KVIEPRAPSL TNDEVEEFRA YFNEKMSILQ KGGKRLEGTE HRQDNDTGNE EQEEEEDDEE EMEEKLAKAK GSQAPSLPNT SEAQKIKEVP TQFLDRDEEE EDADFLKVKR HNVFGLDLKD EKTLQKKEPS KSSIKKKMTK VAEAKKVMKR NFKVNKKITF TDEGELVQQW PQMQKSAIKD AEEDDDTGGI NLHKAKERLQ EEDKFDKEEY RKKIKAKHRE KRLKEREARR EANKRQAKAK DEEEAFLDWS DDDDDDDDGF DPSTLPDPDK YRSSEDSDSE DMENKISDTK KKQGMKKRSN SEVEDVGPTS HNRKKARWDT LEPLDTGLSL AEDEELVLHL LRSQS
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