DNA excision repair protein ERCC-8 (ERCC8)

About DNA excision repair protein ERCC-8

DNA excision repair protein ERCC-8 (ERCC8) is a protein from Homo sapiens identified by UniProt accession Q13216, 396 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.

Target properties

Protein name	DNA excision repair protein ERCC-8
UniProt accession	Q13216
Gene	ERCC8
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (119)

Diseases linked to this target (Open Targets).

Cockayne syndrome type 1 · score 0.85
Cockayne syndrome · score 0.72
UV-sensitive syndrome 2 · score 0.67
UV-sensitive syndrome · score 0.55
genetic disorder · score 0.47
Cockayne syndrome type 2 · score 0.37
Cockayne syndrome type 3 · score 0.37
Abnormality of the nervous system · score 0.27
hearing loss, autosomal recessive · score 0.27
Parkinson disease · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13216-F1	alphafold	PREDICTED	91.61	—

Amino-acid sequence (396 residues)

MLGFLSARQT GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGGGINTLD IEPVEGRYML SGGSDGVIVL YDLENSSRQS YYTCKAVCSI GRDHPDVHRY SVETVQWYPH DTGMFTSSSF DKTLKVWDTN TLQTADVFNF EETVYSHHMS PVSTKHCLVA VGTRGPKVQL CDLKSGSCSH ILQGHRQEIL AVSWSPRYDY ILATASADSR VKLWDVRRAS GCLITLDQHN GKKSQAVESA NTAHNGKVNG LCFTSDGLHL LTVGTDNRMR LWNSSNGENT LVNYGKVCNN SKKGLKFTVS CGCSSEFVFV PYGSTIAVYT VYSGEQITML KGHYKTVDCC VFQSNFQELY SGSRDCNILA WVPSLYEPVP DDDETTTKSQ LNPAFEDAWS SSDEEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards