DnaJ homolog subfamily C member 3 (DNAJC3)

About DnaJ homolog subfamily C member 3

DnaJ homolog subfamily C member 3 (DNAJC3) is a protein from Homo sapiens identified by UniProt accession Q13217, 504 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

Target properties

Protein name	DnaJ homolog subfamily C member 3
UniProt accession	Q13217
Gene	DNAJC3
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (141)

Diseases linked to this target (Open Targets).

juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome · score 0.73
influenza · score 0.38
genetic disorder · score 0.34
clear cell renal carcinoma · score 0.27
FEV/FVC ratio · score 0.27
alkaline phosphatase measurement · score 0.24
urate measurement · score 0.20
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13217-F1	alphafold	PREDICTED	86.53	—

Amino-acid sequence (504 residues)

MVAPGSVTSR LGSVFPFLLV LVDLQYEGAE CGVNADVEKH LELGKKLLAA GQLADALSQF HAAVDGDPDN YIAYYRRATV FLAMGKSKAA LPDLTKVIQL KMDFTAARLQ RGHLLLKQGK LDEAEDDFKK VLKSNPSENE EKEAQSQLIK SDEMQRLRSQ ALNAFGSGDY TAAIAFLDKI LEVCVWDAEL RELRAECFIK EGEPRKAISD LKAASKLKND NTEAFYKIST LYYQLGDHEL SLSEVRECLK LDQDHKRCFA HYKQVKKLNK LIESAEELIR DGRYTDATSK YESVMKTEPS IAEYTVRSKE RICHCFSKDE KPVEAIRVCS EVLQMEPDNV NALKDRAEAY LIEEMYDEAI QDYETAQEHN ENDQQIREGL EKAQRLLKQS QKRDYYKILG VKRNAKKQEI IKAYRKLALQ WHPDNFQNEE EKKKAEKKFI DIAAAKEVLS DPEMRKKFDD GEDPLDAESQ QGGGGNPFHR SWNSWQGFNP FSSGGPFRFK FHFN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards