Chitotriosidase-1 (CHIT1)

About Chitotriosidase-1

Chitotriosidase-1 (CHIT1) is a protein from Homo sapiens identified by UniProt accession Q13231, 466 residues long. MolForge cross-references it against 0 known binders and 325 disease associations.

Target properties

Protein name	Chitotriosidase-1
UniProt accession	Q13231
Gene	CHIT1
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (325)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.43
YKL40 measurement · score 0.36
mean reticulocyte volume · score 0.29
chitotriosidase-1 measurement · score 0.25
cerebrospinal fluid biomarker measurement · score 0.22
high density lipoprotein cholesterol measurement · score 0.21
chitotriosidase deficiency · score 0.21
neurodegenerative disease · score 0.20
reticulocyte count · score 0.15
sarcoidosis · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13231-F1	alphafold	PREDICTED	91.42	—

Amino-acid sequence (466 residues)

MVRSVAWAGF MVLLMIPWGS AAKLVCYFTN WAQYRQGEAR FLPKDLDPSL CTHLIYAFAG MTNHQLSTTE WNDETLYQEF NGLKKMNPKL KTLLAIGGWN FGTQKFTDMV ATANNRQTFV NSAIRFLRKY SFDGLDLDWE YPGSQGSPAV DKERFTTLVQ DLANAFQQEA QTSGKERLLL SAAVPAGQTY VDAGYEVDKI AQNLDFVNLM AYDFHGSWEK VTGHNSPLYK RQEESGAAAS LNVDAAVQQW LQKGTPASKL ILGMPTYGRS FTLASSSDTR VGAPATGSGT PGPFTKEGGM LAYYEVCSWK GATKQRIQDQ KVPYIFRDNQ WVGFDDVESF KTKVSYLKQK GLGGAMVWAL DLDDFAGFSC NQGRYPLIQT LRQELSLPYL PSGTPELEVP KPGQPSEPEH GPSPGQDTFC QGKADGLYPN PRERSSFYSC AAGRLFQQSC PTGLVFSNSC KCCTWN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards