About Noggin
Noggin (NOG) is a protein
from Homo sapiens identified by UniProt accession
Q13253, 232 residues long.
MolForge cross-references it against 0 known binders and
382 disease associations.
Target properties
| Protein name | Noggin |
|---|
| UniProt accession | Q13253 |
|---|
| Gene | NOG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 232 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (382)
Diseases linked to this target (Open Targets).
- proximal symphalangism 1A · score 0.79
- tarsal-carpal coalition syndrome · score 0.75
- brachydactyly type B2 · score 0.74
- multiple synostoses syndrome 1 · score 0.73
- stapes ankylosis with broad thumbs and toes · score 0.71
- multiple synostoses syndrome · score 0.61
- genetic disorder · score 0.47
- refractive error measurement · score 0.42
- body height · score 0.41
- cleft lip · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13253-F1 | alphafold | PREDICTED | 86.08 | — |
Amino-acid sequence (232 residues)
MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC
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