About Mitotic spindle assembly checkpoint protein MAD2A
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) is a protein
from Homo sapiens identified by UniProt accession
Q13257, 205 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Mitotic spindle assembly checkpoint protein MAD2A |
|---|
| UniProt accession | Q13257 |
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| Gene | MAD2L1 |
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| Organism | Homo sapiens |
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| Length | 205 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (156)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.34
- Abnormality of refraction · score 0.27
- systolic blood pressure · score 0.26
- refractive error · score 0.24
- heart disease · score 0.22
- myocardial infarction · score 0.22
- cardiovascular disease · score 0.22
- lung adenocarcinoma · score 0.20
- refractive error measurement · score 0.18
- breast adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13257-F1 | alphafold | PREDICTED | 93.79 | — |
Amino-acid sequence (205 residues)
MALQLSREQG ITLRGSAEIV AEFFSFGINS ILYQRGIYPS ETFTRVQKYG LTLLVTTDLE LIKYLNNVVE QLKDWLYKCS VQKLVVVISN IESGEVLERW QFDIECDKTA KDDSAPREKS QKAIQDEIRS VIRQITATVT FLPLLEVSCS FDLLIYTDKD LVVPEKWEES GPQFITNSEE VRLRSFTTTI HKVNSMVAYK IPVND
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