Interleukin-15 receptor subunit alpha (IL15RA)

About Interleukin-15 receptor subunit alpha

Interleukin-15 receptor subunit alpha (IL15RA) is a protein from Homo sapiens identified by UniProt accession Q13261, 267 residues long. MolForge cross-references it against 0 known binders and 281 disease associations.

Target properties

Protein name	Interleukin-15 receptor subunit alpha
UniProt accession	Q13261
Gene	IL15RA
Organism	Homo sapiens
Length	267 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (281)

Diseases linked to this target (Open Targets).

interleukin 15 receptor subunit alpha measurement · score 0.45
blood protein measurement · score 0.37
cystatin C measurement · score 0.28
soluble interleukin-2 receptor subunit alpha measurement · score 0.20
atopic eczema · score 0.20
response to fenofibrate · score 0.16
monocyte count · score 0.15
Eczematoid dermatitis · score 0.15
inflammatory bowel disease · score 0.12
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13261-F1	alphafold	PREDICTED	64.45	—

Amino-acid sequence (267 residues)

MAPRRARGCR TLGLPALLLL LLLRPPATRG ITCPPPMSVE HADIWVKSYS LYSRERYICN SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA KNWELTASAS HQPPGVYPQG HSDTTVAIST STVLLCGLSA VSLLACYLKS RQTPPLASVE MEAMEALPVT WGTSSRDEDL ENCSHHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards