About Dehydrogenase/reductase SDR family member 2, mitochondrial
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) is a protein
from Homo sapiens identified by UniProt accession
Q13268, 280 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Dehydrogenase/reductase SDR family member 2, mitochondrial |
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| UniProt accession | Q13268 |
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| Gene | DHRS2 |
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| Organism | Homo sapiens |
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| Length | 280 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.10
- esophageal squamous cell carcinoma · score 0.08
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- hepatocellular carcinoma · score 0.05
- pentosuria · score 0.05
- ear infection · score 0.03
- chronic kidney disease · score 0.03
- lung adenocarcinoma · score 0.03
- Granular Cell Tumor · score 0.03
- psoriasis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13268-F1 | alphafold | PREDICTED | 89.75 | — |
Amino-acid sequence (280 residues)
MLSAVARGYQ GWFHPCARLS VRMSSTGIDR KGVLANRVAV VTGSTSGIGF AIARRLARDG AHVVISSRKQ QNVDRAMAKL QGEGLSVAGI VCHVGKAEDR EQLVAKALEH CGGVDFLVCS AGVNPLVGST LGTSEQIWDK ILSVNVKSPA LLLSQLLPYM ENRRGAVILV SSIAAYNPVV ALGVYNVSKT ALLGLTRTLA LELAPKDIRV NCVVPGIIKT DFSKVFHGNE SLWKNFKEHH QLQRIGESED CAGIVSFLCS PDASYVNGEN IAVAGYSTRL
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