About Ras GTPase-activating protein-binding protein 1
Ras GTPase-activating protein-binding protein 1 (G3BP1) is a protein
from Homo sapiens identified by UniProt accession
Q13283, 466 residues long.
MolForge cross-references it against 0 known binders and
191 disease associations.
Target properties
| Protein name | Ras GTPase-activating protein-binding protein 1 |
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| UniProt accession | Q13283 |
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| Gene | G3BP1 |
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| Organism | Homo sapiens |
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| Length | 466 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (191)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- COVID-19 · score 0.37
- creatinine measurement · score 0.30
- Red cell distribution width · score 0.28
- cortical surface area measurement · score 0.18
- cortical thickness · score 0.17
- brain measurement · score 0.14
- platelet component distribution width · score 0.12
- body mass index · score 0.12
- telomere length · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13283-F1 | alphafold | PREDICTED | 66.80 | — |
Amino-acid sequence (466 residues)
MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK PADAVYGQKE IHRKVMSQNF TNCHTKIRHV DAHATLNDGV VVQVMGLLSN NNQALRRFMQ TFVLAPEGSV ANKFYVHNDI FRYQDEVFGG FVTEPQEESE EEVEEPEERQ QTPEVVPDDS GTFYDQAVVS NDMEEHLEEP VAEPEPDPEP EPEQEPVSEI QEEKPEPVLE ETAPEDAQKS SSPAPADIAQ TVQEDLRTFS WASVTSKNLP PSGAVPVTGI PPHVVKVPAS QPRPESKPES QIPPQRPQRD QRVREQRINI PPQRGPRPIR EAGEQGDIEP RRMVRHPDSH QLFIGNLPHE VDKSELKDFF QSYGNVVELR INSGGKLPNF GFVVFDDSEP VQKVLSNRPI MFRGEVRLNV EEKKTRAARE GDRRDNRLRG PGGPRGGLGG GMRGPPRGGM VQKPGFGVGR GLAPRQ
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